Applications in clinical neuroscience

Our groups collaborates with various clinical neuroscience research groups to investigate various diseases, including:

Alzheimer’s Disease (methods: BOLD fMRI, structural and diffusion MRI)

  • Drago V., Babiloni C., Bartrés-Faz D., Caroli A., Bosch B., Hensch T.,  Didic M., Klafki H., Pievani M., Jovicich J., Venturi L., Spitzer P.,  Vecchio F., Schoenknecht P., Wiltfang J., Redolfi A., Forloni G.,  Blin O., Irving E., Davis C., Hårdemark HG., Frisoni G.B. Disease Tracking Markers for Alzheimer’s Disease at the Prodromal (MCI) Stage. J. Alzheimers Dis. 2011, 26 (Supp. 3), 159-199. (PubMed)

Presurgical tumor characterization (methods: BOLD fMRI)

  • Zacà D, Jovicich J, Nadar SR, Voyvodic JT, Pillai JJ. Cerebrovascular reactivity mapping in patients with low grade gliomas undergoing presurgical sensorimotor mapping with BOLD fMRI. J Magn Res Imaging 2014 Aug;40(2):383-90. (PubMed)

Language disorders: semantic aphasia (methods: fMRI connectivity)

  • Guo CC, Gorno-Tempini ML, Gesierich B, Henry M, Trujillo A, Shany-Ur T,Jovicich J, Robinson SD, Kramer JH, Rankin KP, Miller BL, Seeley WW. Anterior temporal lobe degeneration produces widespread network-driven dysfunction. Brain. 2013 136 (Pt 10):2979-91. (PubMed)

  • Gesierich B, Jovicich J, Riello M, Adriani M, Monti A, Brentari V, Robinson SD, Wilson SM, Fairhall SL, Gorno-Tempini ML. Distinct neural substrates for semantic knowledge and naming in the temporoparietal network. Cerebral Cortex. 2012 22(10):2217-26. (PubMed

HIV treatment, attention, memory (methods: BOLD fMRI and MRS)

  • Chang L, Ernst T, Witt MD, Ames N, Walot I, Jovicich J, DeSilva M, Trivedi N, Speck O, Miller EN. Persistent brain abnormalities in antiretroviral-naive HIV patients 3 months after HAART. Antivir Ther. 2003;8(1):17-26. (PubMed)

  • Ernst T, Chang L, Jovicich J, Ames N, Arnold S. Abnormal brain activation on functional MRI in cognitively asymptomatic HIV patients. Neurology. 2002;59(9):1343-9. (PubMed)

  • Chang L, Speck O, Miller EN, Braun J, Jovicich J, Koch C, Itti L, Ernst T. Neural correlates of attention and working memory deficits in HIV patients.Neurology. 2001; 57(6):1001-7.  (PubMed)

Metabolic effects of drugs: Tamoxifen (methods: MRS)

  • Ernst T, Chang L, Cooray D, Salvador C, Jovicich J, Walot I, Boone K, Chlebowski R. The effects of tamoxifen and estrogen on brain metabolism in elderly women. J Natl Cancer Inst. 2002;94(8):592-7.  (PubMed)