Projects

Sublethal effects of neonicotinoids on the honeybee brain: from single neuron imaging to colony studies.

Methods

  • functional imaging of different regions along the odour processing pathway
  • controlled perfusion of the brain with active substances during imaging
  • comparative behavioural studies unsing PER

Objectives

  • determine brain regions sensitive to neonicotinoid pesticides
  • quantify relevant doses for onset of effects in the olfactory system
  • compare effects in the brain to behavioural symtoms in field studies

Partners

Financing

  • 3 year project financed by the Provincia autonoma di Bolzano

Of bees and men: Development of an optogenetic animal model to study oscillatory neural networks.

Methods

  • high temporal resolution imaging of respones to odour stimuli
  • analysis of oscillatory activity in the honeybee brain
  • development of an optogenetic toolbox for real-time modulation of the olfactory processing network

Objectives

  • temporal coding in odour perception
  • connectivity in the olfactory network
  • changes in the network properties under optogenetic modulation of single nodes

Partners

Financing

  • as a Strategic Project by the Università degli studi di Trento

Fundamental processes in odorant receptor interaction: beyond the shape theory of olfaction

Methods

  • studying odour coding of compounds that share chemical properties but differ in molecular vibration and vice versa
  • develope in vitro essays to study odour receptor interaction

Objectives

  • trace back insects' ability to destiguish chemically identical odour compounds
  • study possible influence of molecular vibrations
  • exclude alternative explainations for differential odour coding

Partners

Insect brain imaging: from fundamental neuroscience to pest control

Methods

  • two-photon in vivo imaging of insect brains in vivo to outperform conventional microscopy by spatial and temporal resolution, penetration depth and photodamage limitation

Objectives

  • Odour coding principles in the honeybee brain
  • Morphological and functional plasticity in the honeybee brain after associative or non-associative learning
  • In of odour perception due to neurotoxic pesticides as a possible cause for the western world honeybee population decline (Colony Collapse Disorder)

Financing

  •  as Research unit (IBRAIM) by the Provincia autonoma di Trento

Sustainable strategies against infesting flies: from olfactory perception to a safeguard of small fruits in Trentino

Methods

  • behaviour experiments in Drosophila melanogaster and Drosophila suzukii
  • optical imaging of transgenetic fruitflies

Objectives

  • differences between D. suzukii e D. melanogaster regarding reception, behaviour, and neuroanatomy.
  • development of sostainable strategies to explore these results to couteract the diffusion of D. suzukii.

Partners

Financing

  • by the Communal government of Rovereto

Multifunctional nanohybrid photosensitizers for Photodynamic therapy via X-ray and IR activation

Methods

  • synthetization and functionalization of photo-sensitive silicon Nanowires
  • in vitro experiments on IR activation, and quantification of phototoxic effects

Objectives

  • development of a photosensitizer that is fexibly activatible at very different wavelength
  • characterization of functionality in cell cultures

Partners

  • Roberta Tatti and Roberto Verucchi (Institute of materials for electronics and magnetism, CNR)
  • Thomas Paternoster and Nicola Berti (Sandoz Industries)

Financing

  • by Fondazione Cassa di risparmio di Trento e Rovereto